New Research Publication: PRKG1 Variants and Early-Onset Thoracic Aortic Dissection
A new article from the Montalcino Aortic Consortium (MAC), “PRKG1 pathogenic variants cause thoracic aortic dissection with minimal aortic dilation
Registration Open: Science in Spain Conference (Barcelona, 2026)
Registration and abstract submission are now open for the Science in Spain Conference, hosted by the Marfan Foundation and the European Society of Cardiology’s Peripheral Artery and Aortic Disease Working Group. The conference will take place October 4–7, 2026, in Barcelona, Spain.
Registration Open: 4th Heritable Aortic Disorders Symposium (Vancouver, 2026)
Registration is now open for both medical professionals and patients and families for the 4th Heritable Aortic Disorders Symposium, taking place May 22–23, 2026, in Vancouver, British Columbia.
New Research Publication: ACTA2 Variants and Early-Onset Atherosclerosis
A new article from the Montalcino Aortic Consortium (MAC), “ACTA2 Pathogenic Variants Activating Heat Shock Factor 1 and Increasing Cholesterol Biosynthesis in Smooth Muscle Cells Predispose to Early Onset Atherosclerosis,” explores how genetic variants contribute to early-onset atherosclerosis and advances understanding of vascular disease mechanisms.
Registration Open: American College of Cardiology 75th Annual Scientific Session
Registration is now open for the American College of Cardiology’s 75th Annual Scientific Session & Expo, taking place March 28–30, 2026, in New Orleans, USA.
Call for Research Papers: Special Issue on Aortic Aneurysm
A call for research papers is now open for an upcoming special issue on “Aortic Aneurysm: Mechanisms, Biomarkers, and Therapeutic Strategy” in Biomedicines. Guest edited by MAC members Dr. Esfandiarei and Dr. Tierney, this issue will highlight advances in understanding the pathophysiology, diagnosis, and treatment of aortic aneurysms. Submission deadline: March 31, 2026.
Canadian Cardiovascular Society Releases 2025 Cardiogenetic Testing Update
The Canadian Cardiovascular Society (CCS) has released its 2025 Clinical Practice Update on Cardiogenetic Testing, providing important guidance for clinicians in the diagnosis and management of inherited cardiovascular conditions.
New Research Publication: Arterial Events Across Genetic Conditions
A new MAC study, “Differences in Arterial Events in Vascular Ehlers-Danlos, Loeys-Dietz, and Marfan Syndrome,” provides important insights into how arterial complications vary across genetic aortic disorders, supporting improved risk assessment and patient care.
Dr. Nanette Alvarez Receives Lifetime Achievement Award
Congratulations to Dr. Nanette Alvarez, recipient of the Tirone David Lifetime Achievement Award at the 2025 MAC Summit in Montalcino, Italy, recognizing her outstanding contributions to the field.
New Research Publication: TGFB3-Related Heritable Thoracic Aortic Disease
A MAC publication, “Aortic and arterial manifestations and clinical features in TGFB3-related heritable thoracic aortic disease: results from the Montalcino Aortic Consortium,” provides new insights into the clinical presentation and management of this genetic condition.